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What are the Gonadal Axes, and how do they function in the human body?

Answered on : 2024-01-24

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1. **Definition:** Gonadal Axes refer to the intricate hormonal systems controlling reproductive functions in both males and females.

2. **Components:**

- **Hypothalamic-Pituitary-Gonadal (HPG) Axis:** Governs reproductive hormone release.

- **Gonadotropins:** Hormones (e.g., FSH, LH) influencing gonadal activity.

3. **Function:**

- **Initiation:** Hypothalamus releases GnRH, stimulating the pituitary.

- **Pituitary Response:** Secretes FSH and LH.

- **Gonadal Impact:** FSH and LH stimulate gamete production and sex hormone release.

4. **Regulation:** Feedback mechanisms maintain hormonal balance.

5. **Significance:** Crucial for puberty, fertility, and overall reproductive health.

6. **Clinical Relevance:** Dysregulation linked to mood disorders, alternative reproductive tactics, and disorders like central hypogonadism[2][8][17].

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