What is the A431 cell line and its significance in biomedical research?
Answered on : 2024-01-24
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The A431 cell line is a human cell line derived from an epidermoid carcinoma excised from the skin tissue of an 85-year-old female patient. This cell line exhibits epithelial morphology and is commonly used in biomedical research, particularly in cancer, toxicology, and immuno-oncology studies. A431 cells are known for their abnormal high expression of epidermal growth factor receptor (EGFR), making them a valuable model for studying EGFR-related research. They are used in various experiments related to apoptosis, cell cycle, cell signaling, and EGF (Epidermal Growth Factor) function. A431 cells have a doubling time of approximately 80-100 hours and maintain a stable hypertriploid karyotype. Researchers often use A431 cells to understand cellular processes and test potential therapies or treatments related to cancer and other skin-related conditions [1][2][8].
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