What is the significance of the 180 mCi perchenate limit in the release of patients administered radioactive materials, according to the U.S. Nuclear Regulatory Commission (NRC) guidance?

Answered on : 2024-01-23

Sources

Release of Patients Administered Radioactive Materials

nrc.gov

1

Regulatory Guide 8.39, Release of Patients Administered ...

nrc.gov

2

Regulatory Guide 8.20, Rev. 2, "Applications of Bioassay ...

nrc.gov

3

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1. The NRC issues regulatory guides to specify acceptable methods for releasing patients administered radioactive materials.

2. The 180 mCi perchenate limit is crucial in determining the release eligibility for patients who have received radioactive materials.

3. Patients receiving Tc-99m up to 760 mCi can be released if the dose constraint D(∞) is within 0.18 rem (180 mrem, 1.8 mSv)[4].

4. The I-131 patients given 100 mCi may need to stay in a lead-lined room for at least 24 hours before release[5].

5. The 30 mCi rule, discussed in historical context[7], emphasizes the importance of solid data in regulatory decisions.

6. Regulatory Guide 8.39 and Regulatory Guide 8.20 provide additional details on release methods and bioassay applications[2][3].

Citations:

- [4] : Dosimetry for NM Procedures and Regulations for Releasing Patients

- [5] : Nuclear Regulatory Commission guidance on release of radioactive patients

- [7] : The AEC/NRC 30 mCi rule: regulatory origins and clinical

- [2] : Regulatory Guide 8.39, Release of Patients Administered

- [3] : Regulatory Guide 8.20, Rev. 2, "Applications of Bioassay

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